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Descriptor en español: |
Integrinas
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Descriptor en inglés: | Integrins | ||||||
Descriptor en portugués: | Integrinas | ||||||
Descriptor en francés: | Intégrines | ||||||
Término(s) alternativo(s): |
Integrin |
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Código(s) jeráquico(s): |
D12.776.543.750.705.408 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D016023 | ||||||
Nota de alcance: | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
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Nota de indización: | prefer specifics |
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Calificadores permitidos: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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Indexación anterior: |
Glycoproteins (1966-1987) Membrane Glycoproteins (1988-1989) Receptors, Endogenous Substances (1973-1989) Receptors, Immunologic (1980-1989) |
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Nota Pública de MeSH: | 90 |
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Nota de historia: | 90 |
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Vea también los descriptores: |
Cell Adhesion Molecules
MeSH | ||||||
Identificador de DeCS: | 24746 | ||||||
ID del Descriptor: | D016023 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/1990 | ||||||
Fecha de entrada: | 07/07/1989 | ||||||
Fecha de revisión: | 27/05/2020 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Integrins
- Concepto preferido
UI del concepto |
M0024497 |
Nota de alcance | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
Término preferido | Integrins |
Término(s) alternativo(s) |
Integrin |
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