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Descriptor en español: |
Angiotensinógeno
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Descriptor en inglés: | Angiotensinogen | ||||||
Descriptor en portugués: | Angiotensinogênio | ||||||
Descriptor en francés: | Angiotensinogène | ||||||
Término(s) alternativo(s): |
Hypertensinogen Proangiotensin Renin Substrate Renin Substrate Tetradecapeptide Renin-Substrate SERPINA8 Serpin A8 Tetradecapeptide, Renin Substrate |
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Código(s) jeráquico(s): |
D12.644.456.073.070 D12.644.861.020 D12.776.811.070 D12.776.872.020 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000808 | ||||||
Nota de alcance: | An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Acción Farmacológica: |
Inhibidores de Serina Proteinasa |
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Número de registro: | 11002-13-4 | ||||||
Nombre CAS Tipo 1: | Angiotensinogen (protein renin substrate) | ||||||
Indexación anterior: |
Alpha Globulins (1968-1974) Angiotensin II (1968-1974) Protein Precursors (1971-1974) |
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Nota Pública de MeSH: | 87; was see under ANGIOTENSINS 1975-86 |
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Nota de historia: | 87(75); was see under ANGIOTENSINS 1975-86 |
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Identificador de DeCS: | 27913 | ||||||
ID del Descriptor: | D000808 | ||||||
Clasificación de la NLM: | QU 68 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/1987 | ||||||
Fecha de entrada: | 19/11/1974 | ||||||
Fecha de revisión: | 09/06/2020 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Angiotensinogen
- Concepto preferido
Renin Substrate Tetradecapeptide
- Más estrecho
UI del concepto |
M0001208 |
Nota de alcance | An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. |
Término preferido | Angiotensinogen |
Término(s) alternativo(s) |
Hypertensinogen Proangiotensin Renin Substrate Renin-Substrate SERPINA8 Serpin A8 |
UI del concepto |
M0001209 |
Nota de alcance | A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities. |
Término preferido | Renin Substrate Tetradecapeptide |
Término(s) alternativo(s) |
Tetradecapeptide, Renin Substrate |
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