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Descriptor en español: |
Ciclosoma-Complejo Promotor de la Anafase
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Descriptor en inglés: | Anaphase-Promoting Complex-Cyclosome | ||||||
Descriptor en portugués: | Ciclossomo-Complexo Promotor de Anáfase | ||||||
Descriptor en francés: | Complexe promoteur de l'anaphase | ||||||
Término(s) alternativo(s): |
Anaphase Promoting Complex |
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Código(s) jeráquico(s): |
D08.811.464.938.750.092 D12.776.167.024 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D064173 | ||||||
Nota de alcance: | An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 2.3.2.27 | ||||||
Indexación anterior: |
Ligases (1992-2003) Ubiquitin-Protein Ligase Complexes (2004-2013) |
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Nota Pública de MeSH: | 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013 |
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Nota de historia: | 2014 |
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Identificador de DeCS: | 55272 | ||||||
ID del Descriptor: | D064173 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/2014 | ||||||
Fecha de entrada: | 08/07/2013 | ||||||
Fecha de revisión: | 02/06/2016 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Anaphase-Promoting Complex-Cyclosome
- Concepto preferido
UI del concepto |
M0580077 |
Nota de alcance | An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. |
Término preferido | Anaphase-Promoting Complex-Cyclosome |
Término(s) alternativo(s) |
Anaphase Promoting Complex |
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