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| Descriptor en español: |
Proteína 1 que Contiene Dominios SAM y HD
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| Descriptor en inglés: | SAM Domain and HD Domain-Containing Protein 1 | ||||||
| Descriptor en portugués: | Proteína 1 com Domínio SAM e Domínio HD | ||||||
| Descriptor en francés: | Protéine-1 contenant un domaine SAM et un domaine HD | ||||||
| Término(s) alternativo(s): |
SAM Domain and HD Domain Containing Protein 1 SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase SAMHD1 Protein SAMHD1 dNTPase |
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| Código(s) jeráquico(s): |
D08.811.277.040.725 D08.811.277.352.700.843 D12.776.066.375 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000076106 | ||||||
| Nota de alcance: | A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). |
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| Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Número de registro: | EC 3.1.5.- | ||||||
| Indexación anterior: |
Monomeric GTP-Binding Proteins (2004-2017) |
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| Nota Pública de MeSH: | 2018 |
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| Nota de historia: | 2018 |
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| Identificador de DeCS: | 57002 | ||||||
| ID del Descriptor: | D000076106 | ||||||
| Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
| Fecha de establecimiento: | 01/01/2018 | ||||||
| Fecha de entrada: | 11/07/2017 | ||||||
| Fecha de revisión: | 29/06/2017 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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SAM Domain and HD Domain-Containing Protein 1
- Concepto preferido
| UI del concepto |
M000632192 |
| Nota de alcance | A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). |
| Término preferido | SAM Domain and HD Domain-Containing Protein 1 |
| Término(s) alternativo(s) |
SAM Domain and HD Domain Containing Protein 1 SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase SAMHD1 Protein SAMHD1 dNTPase |
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