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| Descriptor en español: |
Proteína del Grupo de Complementación N de la Anemia de Fanconi
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| Descriptor en inglés: | Fanconi Anemia Complementation Group N Protein | ||||||
| Descriptor en portugués: | Proteína do Grupo de Complementação N da Anemia de Fanconi | ||||||
| Descriptor en francés: | Protéine du groupe de complémentation N de l'anémie de Fanconi | ||||||
| Término(s) alternativo(s): |
FANCN Protein PALB2 Protein Partner and Localizer of BRCA2 Protein |
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| Código(s) jeráquico(s): |
D12.776.313.953 D12.776.624.776.051 D12.776.660.323 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000076164 | ||||||
| Nota de alcance: | A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. |
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| Calificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Indexación anterior: |
Nuclear Proteins (2006-2017) Tumor Suppressor Proteins (2006-2017) |
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| Nota Pública de MeSH: | 2018 |
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| Nota de historia: | 2018 |
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| Identificador de DeCS: | 57122 | ||||||
| ID del Descriptor: | D000076164 | ||||||
| Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
| Fecha de establecimiento: | 01/01/2018 | ||||||
| Fecha de entrada: | 11/07/2017 | ||||||
| Fecha de revisión: | 29/06/2017 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Fanconi Anemia Complementation Group N Protein
- Concepto preferido
| UI del concepto |
M000632389 |
| Nota de alcance | A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. |
| Término preferido | Fanconi Anemia Complementation Group N Protein |
| Término(s) alternativo(s) |
FANCN Protein PALB2 Protein Partner and Localizer of BRCA2 Protein |
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