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Descriptor en español: |
Proteína NEDD8
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Descriptor en inglés: | NEDD8 Protein | ||||||
Descriptor en portugués: | Proteína NEDD8 | ||||||
Descriptor en francés: | Protéine NEDD8 | ||||||
Término(s) alternativo(s): |
NEDD 8 Protein NEDD-8 Protein NEDD8, Ubiquitin-like Protein Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8 Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 Ubiquitin like Protein NEDD8 Ubiquitin-like Protein NEDD8 |
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Código(s) jeráquico(s): |
D12.776.947.218 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000075687 | ||||||
Nota de alcance: | A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Indexación anterior: |
Ubiquitins (1993-2017) |
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Nota Pública de MeSH: | 2018 |
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Nota de historia: | 2018 |
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Identificador de DeCS: | 57143 | ||||||
ID del Descriptor: | D000075687 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/2018 | ||||||
Fecha de entrada: | 11/07/2017 | ||||||
Fecha de revisión: | 29/06/2017 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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NEDD8 Protein
- Concepto preferido
UI del concepto |
M000631126 |
Nota de alcance | A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins |
Término preferido | NEDD8 Protein |
Término(s) alternativo(s) |
NEDD 8 Protein NEDD-8 Protein NEDD8, Ubiquitin-like Protein Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8 Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 Ubiquitin like Protein NEDD8 Ubiquitin-like Protein NEDD8 |
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