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Descripteur en français: Débrisoquine
Descripteur en anglais: Debrisoquin
Descripteur en espagnol: Debrisoquina
Descripteur debrisoquina
Note d'application: Fármaco neuro-bloqueante adrenérgica similar en efectos a la GUANETIDINA. Hay que señalar también su función como sustrato de la enzima polimórfica del citocromo P-450. Personas con ciertas isoformas de esta enzima son incapaces de metabolizar adecuadamente esta y otras muchas sustancias clínicamente importantes. Se piensa que tiene un polimorfismo como el de la debrisoquina 4-hidroxilasa.
Descripteur en portugais: Debrisoquina
Synonymes: Debrisoquine
Tendor
Code(s) d'arborescence: D03.633.100.531.205
Identificateur unique RDF: https://id.nlm.nih.gov/mesh/D003647
Note d'application: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Qualificatifs autorisés: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Action Pharmacologique: Antihypertenseurs
Sympatholytiques
Agents adrénergiques
Numéro de registre: X31CDK040E
Nom CAS Type 1: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
Indexation précédente: Antihypertensive Agents (1966-1972)
Isoquinolines (1969-1972)
Note publique MeSH: 91; was see under ISOQUINOLINES 1973-90
Note historique: 91(73); was see under ISOQUINOLINES 1973-90
Identifiant DeCS: 3665
ID du Descripteur: D003647
Documents indexés dans la Biblioteque Virtuelle de Santé (BVS): Cliquez ici pour accéder aux documents VHL
Date d'établissement: 01/01/1991
Date d'entrée: 01/01/1999
Date de révision: 28/05/2016
Debrisoquin - Concept préféré
Concept UI M0005709
Note d'application An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Terme préféré Debrisoquin
Synonymes Debrisoquine
Tendor - Plus spécifique
Concept UI M0005710
Terme préféré Tendor



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