Recherche
Descripteur en français: Sites fragiles de chromosome
Descripteur en anglais: Chromosome Fragile Sites
Descripteur en espagnol: Sitios Frágiles del Cromosoma
Descripteur sitios frágiles de los cromosomas
Synonymes sítios cromosómicos frágiles
sítios frágiles cromosómicos
Note d'application: Loci específicos que se muestran durante la CARIOTIPIFICACIÓN como una brecha (tramo no condensado a mayor aumento) en un brazo de la CROMÁTIDE después de cultivar las células en condiciones específicas. Estos sitios se asocian con un aumento de la FRAGILIDAD CROMOSÓMICA. Se clasifican como frecuentes o raros, y según las condiciones específicas de cultivo en las que se desarrollan. Los loci de los sitios frágiles se denominan con las "FRA" seguidas por una designación del cromosoma específico y una letra que se refiere al sitio frágil de ese cromosoma (p. ej., FRAXA se refiere al sitio frágil A en el cromosoma X. Es un sitio frágil, raro y sensible al ácido fólico que se asocia al SÍNDROME DEL CROMOSOMA X FRÁGIL).
Descripteur en portugais: Sítios Frágeis do Cromossomo
Synonymes: Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile
Code(s) d'arborescence: G05.360.340.024.189.610
Identificateur unique RDF: https://id.nlm.nih.gov/mesh/D043283
Note d'application: Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Qualificatifs autorisés: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Indexation précédente: Chromosome Fragility (1982-2003)
Note publique MeSH: 2004; see CHROMOSOME FRAGILITY 1982-2003
Note historique: 2004; use CHROMOSOME FRAGILITY 1982-2003
Voir aussi le(s) descripteur(s): Chromosome Fragility MeSH
DNA Repeat Expansion MeSH
Fragile X Syndrome MeSH
Identifiant DeCS: 38395
ID du Descripteur: D043283
Documents indexés dans la Biblioteque Virtuelle de Santé (BVS): Cliquez ici pour accéder aux documents VHL
Date d'établissement: 01/01/2004
Date d'entrée: 09/07/2003
Date de révision: 09/07/2013
Chromosome Fragile Sites - Concept préféré
Concept UI M0004412
Note d'application Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Terme préféré Chromosome Fragile Sites
Synonymes Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile



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