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Descripteur en français: | Diversité des anticorps | ||||||
Descripteur en anglais: | Antibody Diversity | ||||||
Descripteur en espagnol: |
Diversidad de Anticuerpos
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Descripteur en portugais: | Diversidade de Anticorpos | ||||||
Synonymes: |
Antibody Diversities Diversities, Antibody Diversity, Antibody Germ Line Theories Germ Line Theory Theories, Germ Line Theory, Germ Line |
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Code(s) d'arborescence: |
G05.365.036 G12.500.199 |
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Identificateur unique RDF: | https://id.nlm.nih.gov/mesh/D000916 | ||||||
Note d'application: | The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS. |
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Qualificatifs autorisés: |
DE drug effects GE genetics IM immunology PH physiology RE radiation effects |
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Indexation précédente: |
Antibodies (1966-1969) Antibody Specificity (1970-1979) |
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Note publique MeSH: | 80 |
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Note historique: | 80 |
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Identifiant DeCS: | 926 | ||||||
ID du Descripteur: | D000916 | ||||||
Documents indexés dans la Biblioteque Virtuelle de Santé (BVS): | Cliquez ici pour accéder aux documents VHL | ||||||
Date d'établissement: | 01/01/1980 | ||||||
Date d'entrée: | 23/02/1979 | ||||||
Date de révision: | 22/06/2015 |
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PHENOMENA AND PROCESSES
Genetic Phenomena [G05]Genetic Phenomena -
PHENOMENA AND PROCESSES
Immune System Phenomena [G12]Immune System Phenomena
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Antibody Diversity
- Concept préféré
Germ Line Theory
- Plus spécifique
Concept UI |
M0001364 |
Note d'application | The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS. |
Terme préféré | Antibody Diversity |
Synonymes |
Antibody Diversities Diversities, Antibody Diversity, Antibody |
Concept UI |
M0001365 |
Terme préféré | Germ Line Theory |
Synonymes |
Germ Line Theories Theories, Germ Line Theory, Germ Line |
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