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Descritor em português: Complexo Piruvato Desidrogenase
Descritor em inglês: Pyruvate Dehydrogenase Complex
Descritor em espanhol: Complejo Piruvato Deshidrogenasa
Descritor complejo de la piruvato deshidrogenasa
Termo(s) alternativo(s) complejo de piruvato deshidrogenasa
Nota de escopo: Complejo multienzimático responsable de la formación de ACETIL COENZIMA A a partir del piruvato. Las enzimas componentes son la PIRUVATO DESHIDROGENASA (LIPOAMIDA), la dihidrolipoamida acetiltransferasa y la LIPOAMIDA DESHIDROGENASA. El complejo piruvato deshidrogenasa es objeto de tres tipos de control: es inhibido por la acetil-CoA y el NADH; es influído por el estado energético de la célula; y es inhibido cuando un residuo específico de serina de la piruvato descarboxilasa es fosforilado por ATP. La PIRUVATO DESHIDROGENASA (LIPOAMIDA)-FOSFATASA cataliza la reactivación del complejo. (Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Descritor em francês: Complexe du pyruvate déshydrogénase
Termo(s) alternativo(s): Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate
Código(s) hierárquico(s): D05.500.562.625
D08.811.600.741
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D011768
Nota de escopo: A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Combinação de entrada: deficiency:Pyruvate Dehydrogenase Complex Deficiency Disease
Indexação Anterior: Oxidoreductases (1966-1972)
Pyruvate Oxidase (1966-1972)
Pyruvates (1966-1972)
Nota MeSH pública: 74
Nota histórica: 74(73)
Identificador DeCS: 12205
ID do descritor: D011768
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1974
Data de entrada: 01/01/1999
Data de revisão: 08/07/2008
Pyruvate Dehydrogenase Complex - Conceito preferido
Identificador do conceito M0018291
Nota de escopo A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Termo preferido Pyruvate Dehydrogenase Complex
Termo(s) alternativo(s) Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate



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