Visão selecionada em Inglês
| Descritor em português: | Properdina | ||||||
| Descritor em inglês: | Properdin | ||||||
| Descritor em espanhol: |
Properdina
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| Descritor em francês: | Properdine | ||||||
| Termo(s) alternativo(s): |
Complement Factor P Factor P, Complement |
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| Código(s) hierárquico(s): |
D12.776.124.486.274.965 D12.776.124.790.223.624 D12.776.377.715.182.624 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D011414 | ||||||
| Nota de escopo: | A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections. |
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| Qualificadores permitidos: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Ação Farmacológica: |
Fatores Imunológicos |
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| Número de registro: | 11016-39-0 | ||||||
| Nome CAS Tipo 1: | Complement factor P | ||||||
| Identificador DeCS: | 22267 | ||||||
| ID do descritor: | D011414 | ||||||
| Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
| Data de estabelecimento: | 01/01/1966 | ||||||
| Data de entrada: | 01/01/1999 | ||||||
| Data de revisão: | 23/06/2015 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Properdin
- Conceito preferido
| Identificador do conceito |
M0017748 |
| Nota de escopo | A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections. |
| Termo preferido | Properdin |
| Termo(s) alternativo(s) |
Complement Factor P Factor P, Complement |
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