Pesquisa
Descritor em português: Aromatase
Descritor em inglês: Aromatase
Descritor em espanhol: Aromatasa
Descritor aromatasa
Termo(s) alternativo(s) CYP19
citocromo P-450 CYP19
citocromo P-450(AROM)
Nota de escopo: Enzima que cataliza la desaturación (aromatización) del anillo A de los andrógenos C19 y los convierte en estrógenos C18. En este proceso se elimina 19-metilo. Esta enzima está unida a la membrana, localizada en el retículo endoplasmático de las células productoras de estrógenos de los ovarios, la placenta, los testículos, el tejido adiposo y el cerebral. El gen CYP19 codifica la aromatasa, y funciona formando un complejo con la NADPH-FERRIHEMOPROTEÍNA REDUCTASA en el sistema del citocromo P-450.
Descritor em francês: Aromatase
Termo(s) alternativo(s): Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19
Código(s) hierárquico(s): D08.244.453.489.500
D08.244.453.915.099
D08.811.682.690.708.170.447.500
D08.811.682.690.708.170.915.099
D12.776.422.220.453.489.500
D12.776.422.220.453.915.099
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D001141
Nota de escopo: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Combinação de entrada: antagonists & inhibitors:Aromatase Inhibitors
Número de registro: EC 1.14.14.1
Indexação Anterior: Androstanes (1972-1974)
Estrogens (1972-1974)
Oxidoreductases (1972-1974)
Nota MeSH pública: 86; was see under OXIDOREDUCTASES 1975-85
Nota histórica: 86(75); was see under OXIDOREDUCTASES 1975-85
Identificador DeCS: 23161
ID do descritor: D001141
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1986
Data de entrada: 19/11/1974
Data de revisão: 27/05/2016
Aromatase - Conceito preferido
Identificador do conceito M0001707
Nota de escopo An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Termo preferido Aromatase
Termo(s) alternativo(s) Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19



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