Pesquisa
Descritor em português: Cloranfenicol O-Acetiltransferase
Descritor em inglês: Chloramphenicol O-Acetyltransferase
Descritor em espanhol: Cloranfenicol O-Acetiltransferasa
Descritor cloramfenicol O-acetiltransferasa
Termo(s) alternativo(s) cloranfenicol acetiltransferasa
enzima CAT
Nota de escopo: Enzima que cataliza la acetilación del cloranfenicol dando lugar a cloranfenicol 3-acetato. Como el cloranfenicol 3-acetato no se une a los ribosomas bacterianos y no es un inhibidor de peptidiltransferasa, la enzima es la responsable de la resistencia natural de las bacterias al cloranfenicol. La enzima, de la que se conocen variantes, está presente en bacterias gramnegativas y grampositivas. EC 2.3.1.28.
Descritor em francês: Chloramphenicol O-acetyltransferase
Termo(s) alternativo(s): Acetyltransferase, Chloramphenicol
CAT Enzyme
Chloramphenicol Acetyltransferase
Chloramphenicol O Acetyltransferase
Chloramphenicol Transacetylase
Enzyme, CAT
O-Acetyltransferase, Chloramphenicol
Transacetylase, Chloramphenicol
Código(s) hierárquico(s): D08.811.913.050.134.170
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D015500
Nota de escopo: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: EC 2.3.1.28
Nome CAS Tipo 1: Acetyl-CoA-chloramphenicol 3-O-acetyltransferase
Indexação Anterior: Acetyltransferases (1973-1988)
Transferases (1966-1972)
Nota MeSH pública: 98(89); see CHLORAMPHENICOL ACETYLTRANSFERASE 1989-97
Nota histórica: 98(89)
Veja também os descritores: Chloramphenicol Resistance MeSH
Identificador DeCS: 23584
ID do descritor: D015500
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1989
Data de entrada: 13/07/1988
Data de revisão: 09/07/2003
Chloramphenicol O-Acetyltransferase - Conceito preferido
Identificador do conceito M0023862
Nota de escopo An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Termo preferido Chloramphenicol O-Acetyltransferase
Termo(s) alternativo(s) Acetyltransferase, Chloramphenicol
CAT Enzyme
Chloramphenicol Acetyltransferase
Chloramphenicol O Acetyltransferase
Chloramphenicol Transacetylase
Enzyme, CAT
O-Acetyltransferase, Chloramphenicol
Transacetylase, Chloramphenicol



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