Visão selecionada em Inglês
Descritor em português: | Neprilisina | ||||||
Descritor em inglês: | Neprilysin | ||||||
Descritor em espanhol: |
Neprilisina
| ||||||
Descritor em francês: | Néprilysine | ||||||
Termo(s) alternativo(s): |
Antigen, CD10 Antigens, CD10 Antigens, Leukemia, Common Acute Lymphoblastic Atriopeptidase CALLA Antigen CD10 Antigen CD10 Antigens Carboxypeptidase, Enkephalin Dipeptidyl Common Acute Lymphoblastic Leukemia Antigens Dipeptidyl Carboxypeptidase, Enkephalin Endopeptidase 24.11 Endopeptidase 24.11, Neutral Endopeptidase, Neutral Endopeptidase-24.11 Enkephalin Dipeptidyl Carboxypeptidase Enkephalinase Enkephalinase 24.11 Enkephalinase-24.11 Enzyme, YGG-Forming Kidney Brush Border Neutral Proteinase Kidney-Brush-Border Neutral Proteinase Membrane Metallo Endopeptidase Membrane Metallo-Endopeptidase Metallo-Endopeptidase, Membrane Metalloendopeptidase, Thermolysin-Like Neutral Endopeptidase Neutral Endopeptidase 24.11 Neutral Proteinase, Kidney-Brush-Border Thermolysin Like Metalloendopeptidase Thermolysin-Like Metalloendopeptidase YGG Forming Enzyme YGG-Forming Enzyme |
||||||
Código(s) hierárquico(s): |
D08.811.277.656.300.480.600 D08.811.277.656.675.374.600 D23.050.285.550 D23.101.140.500 |
||||||
Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D015260 | ||||||
Nota de escopo: | Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. |
||||||
Qualificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
||||||
Número de registro: | EC 3.4.24.11 | ||||||
Indexação Anterior: |
Metalloproteinases (1987-1988) Peptide Peptidohydrolases (1966-1987) |
||||||
Nota MeSH pública: | 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002 |
||||||
Nota Online: | use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92 |
||||||
Nota histórica: | 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92 |
||||||
Identificador DeCS: | 23757 | ||||||
ID do descritor: | D015260 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/1989 | ||||||
Data de entrada: | 18/05/1988 | ||||||
Data de revisão: | 24/05/2017 |
-
-
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
|
Neprilysin
- Conceito preferido
Identificador do conceito |
M0023500 |
Nota de escopo | Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. |
Termo preferido | Neprilysin |
Termo(s) alternativo(s) |
Antigen, CD10 Antigens, CD10 Antigens, Leukemia, Common Acute Lymphoblastic Atriopeptidase CALLA Antigen CD10 Antigen CD10 Antigens Carboxypeptidase, Enkephalin Dipeptidyl Common Acute Lymphoblastic Leukemia Antigens Dipeptidyl Carboxypeptidase, Enkephalin Endopeptidase 24.11 Endopeptidase 24.11, Neutral Endopeptidase, Neutral Endopeptidase-24.11 Enkephalin Dipeptidyl Carboxypeptidase Enkephalinase Enkephalinase 24.11 Enkephalinase-24.11 Enzyme, YGG-Forming Kidney Brush Border Neutral Proteinase Kidney-Brush-Border Neutral Proteinase Membrane Metallo Endopeptidase Membrane Metallo-Endopeptidase Metallo-Endopeptidase, Membrane Metalloendopeptidase, Thermolysin-Like Neutral Endopeptidase Neutral Endopeptidase 24.11 Neutral Proteinase, Kidney-Brush-Border Thermolysin Like Metalloendopeptidase Thermolysin-Like Metalloendopeptidase YGG Forming Enzyme YGG-Forming Enzyme |
Queremos a sua opinião sobre o novo sitio web do DeCS/MeSH
Convidamos-lhe a responder a uma pesquisa que não levará mais que 3 minutos
Ir para pesquisa