Pesquisa
Descritor em português: Fator XIIa
Descritor em inglês: Factor XIIa
Descritor em espanhol: Factor XIIa
Descritor factor XIIa
Termo(s) alternativo(s) factor 12A
factor XII activado
factor XIIa de la coagulación
factor doce A
Nota de escopo: Forma activada del factor XII. En el primer paso de la vía intrínseca de la coagulación sanguínea, la calicreína (con QUININÓGENO DE ALTO PESO MOLECULAR como cofactor) segmenta el factor XII y forma el factor XIIa. Entonces este es escindido de nuevo por la calicreína, la plasmina y la tripsina, dando lugar a fragmentos menores del factor XII (fragmentos del factor de Hageman). Estos fragmentos aumentan la actividad de la precalicreína a calicreína, pero disminuyen la actividad procoagulante del factor XII.
Descritor em francês: Facteur XIIa
Termo(s) alternativo(s): Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Fragments, Hageman-Factor
Hageman Factor Fragments
Hageman-Factor Fragments
Prekallikrein Activator
Código(s) hierárquico(s): D08.811.277.656.300.760.324
D08.811.277.656.959.350.324
D12.776.124.125.450.324
D23.119.450.324
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D015956
Nota de escopo: Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Nota de indexação: /defic = FACTOR XII DEFICIENCY
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: EC 3.4.21.38
Indexação Anterior: Factor XII (1966-1989)
Peptide Fragments (1979-1987)
Serine Proteinases (1988-1989)
Nota MeSH pública: 90
Nota histórica: 90
Veja também os descritores: Coagulants MeSH
Identificador DeCS: 24648
ID do descritor: D015956
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1990
Data de entrada: 25/05/1989
Data de revisão: 24/02/2017
Factor XIIa - Conceito preferido
Identificador do conceito M0024400
Nota de escopo Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Termo preferido Factor XIIa
Termo(s) alternativo(s) Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Prekallikrein Activator
Hageman-Factor Fragments - Mais específico
Identificador do conceito M0024401
Termo preferido Hageman-Factor Fragments
Termo(s) alternativo(s) Fragments, Hageman-Factor
Hageman Factor Fragments



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