Pesquisa
Descritor em português: Integrinas
Descritor em inglês: Integrins
Descritor em espanhol: Integrinas
Descritor integrinas
Termo(s) alternativo(s) integrina
Nota de escopo: Familia de glicoproteínas transmembrana (GLICOPROTEÍNAS DE MEMBRANA), constituidas por heterodímeros no covalentes. Interactúan con una gran variedad de ligandos, incluidas las PROTEÍNAS DE LA MATRIZ EXTRACELULAR, las PROTEÍNAS DEL SISTEMA DEL COMPLEMENTO y otras células, mientras que sus dominios intracelulares interactúan con el CITOESQUELETO. Se han identificado al menos tres familias de integrinas: los RECEPTORES DE CITOADHESINA, los RECEPTORES DE ADHESIÓN LEUCOCITARIA y los RECEPTORES DE ANTÍGENOS MUY TARDÍOS. Cada familia tiene una subunidad beta común (CADENAS BETA DE INTEGRINAS) combinada con una o más subunidades alfa diferentes (CADENAS ALFA DE INTEGRINAS). Estos receptores participan en la adhesión célula-matriz y célula-célula en muchos procesos fisiológicos importantes, como el desarrollo embrionario, la HEMOSTASIA, la TROMBOSIS, la CICATRIZACIÓN DE HERIDAS, los mecanismos de defensa inmunitaria y no inmunitaria y la transformación oncogénica.
Descritor em francês: Intégrines
Termo(s) alternativo(s): Integrin
Código(s) hierárquico(s): D12.776.543.750.705.408
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D016023
Nota de escopo: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Nota de indexação: prefer specifics
Qualificadores permitidos: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Indexação Anterior: Glycoproteins (1966-1987)
Membrane Glycoproteins (1988-1989)
Receptors, Endogenous Substances (1973-1989)
Receptors, Immunologic (1980-1989)
Nota MeSH pública: 90
Nota histórica: 90
Veja também os descritores: Cell Adhesion Molecules MeSH
Identificador DeCS: 24746
ID do descritor: D016023
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1990
Data de entrada: 07/07/1989
Data de revisão: 27/05/2020
Integrins - Conceito preferido
Identificador do conceito M0024497
Nota de escopo A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Termo preferido Integrins
Termo(s) alternativo(s) Integrin



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