Pesquisa
Descritor em português: Osteocalcina
Descritor em inglês: Osteocalcin
Descritor em espanhol: Osteocalcina
Descritor osteocalcina
Termo(s) alternativo(s) proteína Gla ósea
proteína de unión al calcio dependiente de vitamina K
proteína ósea dependiente de vitamina K
Nota de escopo: Proteína fijadora de calcio dependiente de la vitamina K sintetizada por los OSTEOBLASTOS que se encuentra principalmente en los HUESOS. Las determinaciones séricas de osteocalcina aportan un marcador específico no invasivo del metabolismo óseo. La proteína contiene tres residuos del aminoácido ácido gamma-carboxiglutámico (Gla), que, en presencia de CALCIO, promueve la fijación a la HIDROXIAPATITA y la posterior acumulación en la MATRIZ ÓSEA.
Descritor em francês: Ostéocalcine
Termo(s) alternativo(s): 4 Carboxyglutamic Protein, Bone
4-Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone Gla Protein
Bone gamma Carboxyglutamic Acid Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Vitamin K-Dependent Bone Protein
Código(s) hierárquico(s): D12.776.157.125.700
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D015675
Nota de escopo: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: 104982-03-8
Nome CAS Tipo 1: Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-
Indexação Anterior: 1-Carboxyglutamic Acid (1978-1981)
Binding Proteins (1978-1980)
Calcium (1978-1980)
Calcium-Binding Proteins (1980-1989)
Proteins (1980-1981)
Nota MeSH pública: 90; GLA-PROTEIN was see OSTEOCALCIN 1990-96
Nota Online: use OSTEOCALCIN to search GLA-PROTEIN 1990-96
Nota histórica: 90; GLA-PROTEIN was see OSTEOCACLIN 1990-96
Identificador DeCS: 24820
ID do descritor: D015675
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1990
Data de entrada: 06/09/1989
Data de revisão: 07/07/2004
Osteocalcin - Conceito preferido
Identificador do conceito M0024030
Nota de escopo Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Termo preferido Osteocalcin
Termo(s) alternativo(s) 4 Carboxyglutamic Protein, Bone
4-Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone Gla Protein
Bone gamma Carboxyglutamic Acid Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Vitamin K-Dependent Bone Protein



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