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Descritor em português: | Fator de Crescimento Transformador beta | ||||||
Descritor em inglês: | Transforming Growth Factor beta | ||||||
Descritor em espanhol: |
Factor de Crecimiento Transformador beta
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Descritor em francês: | Facteur de croissance transformant bêta | ||||||
Termo(s) alternativo(s): |
Bone Derived Transforming Growth Factor Bone-Derived Transforming Growth Factor Factor, Milk Growth Growth Factor, Milk Milk Growth Factor Platelet Transforming Growth Factor TGF-beta TGFbeta |
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Código(s) hierárquico(s): |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D016212 | ||||||
Nota de escopo: | A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. |
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Qualificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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Indexação Anterior: |
Peptides (1983-1988) Transforming Growth Factors (1989-1990) |
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Nota MeSH pública: | 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90 |
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Nota Online: | use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90 |
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Nota histórica: | 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90 |
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Identificador DeCS: | 29139 | ||||||
ID do descritor: | D016212 | ||||||
Classificação da NLM: | QU 107 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/1991 | ||||||
Data de entrada: | 29/06/1990 | ||||||
Data de revisão: | 02/06/2015 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Transforming Growth Factor beta
- Conceito preferido
Identificador do conceito |
M0024757 |
Nota de escopo | A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. |
Termo preferido | Transforming Growth Factor beta |
Termo(s) alternativo(s) |
Bone Derived Transforming Growth Factor Bone-Derived Transforming Growth Factor Factor, Milk Growth Growth Factor, Milk Milk Growth Factor Platelet Transforming Growth Factor TGF-beta TGFbeta |
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