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Descritor em português: Neoplasia Endócrina Múltipla Tipo 1
Descritor em inglês: Multiple Endocrine Neoplasia Type 1
Descritor em espanhol: Neoplasia Endocrina Múltiple Tipo 1
Descritor neoplasia endocrina múltiple tipo 1
Termo(s) alternativo(s) NEM 1
síndrome de Wermer
Nota de escopo: Síndrome poco frecuente caracterizado por hiperplasia y/o neoplasia de la hipófisis, glándulas paratiroideas, e islotes pancreáticos. En el 90 por ciento de los casos hay hiperparatiroidismo que generalmente es la primera manifestación del síndrome. La manifestación pancreática más frecuente es el gastrinoma que produce típicamente Síndrome de Zollinger-Ellison. La aparición de esté síndrome ha sido limitada a la pérdida de la heterocigosidad alélica del locus 11q13 en el brazo largo del cromosoma 11. Los pacientes, en conjunto, muestran largos períodos de supervivencia. La quimioterapia se utiliza con poca frecuencia y el tratamiento quirúrgico generalmente depende de la expresión genética en cada paciente individualizado. (Traducción libre del original: Holland et al., Cancer Medicine, 3d ed, pp1169-72)
Descritor em francês: Néoplasie endocrinienne multiple de type 1
Termo(s) alternativo(s): Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome
Código(s) hierárquico(s): C04.588.322.400.500
C04.651.600.500
C04.700.630.500
C16.320.700.630.500
C19.344.400.500
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D018761
Nota de escopo: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Nota de indexação: coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Qualificadores permitidos: BL blood
BS blood supply
CF cerebrospinal fluid
CH chemistry
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SC secondary
SU surgery
TH therapy
UL ultrastructure
UR urine
VE veterinary
VI virology
Indexação Anterior: Multiple Endocrine Neoplasia (1972-1994)
Nota MeSH pública: 95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Nota Online: use MULTIPLE ENDOCRINE NEOPLASIA to search MEA I, MEN I, & WERMER SYNDROME 1983-94
Nota histórica: 95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Versão alternativa: MULTIPLE ENDOCRINE NEOPL TYPE 1
Identificador DeCS: 32134
ID do descritor: D018761
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1995
Data de entrada: 23/05/1994
Data de revisão: 24/02/2017
Multiple Endocrine Neoplasia Type 1 - Conceito preferido
Identificador do conceito M0028096
Nota de escopo A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Termo preferido Multiple Endocrine Neoplasia Type 1
Termo(s) alternativo(s) Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome



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