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| Descritor em português: | Proteínas Associadas à Resistência a Múltiplos Medicamentos | ||||||
| Descritor em inglês: | Multidrug Resistance-Associated Proteins | ||||||
| Descritor em espanhol: |
Proteínas Asociadas a Resistencia a Múltiples Medicamentos
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| Descritor em francês: | Protéines associées à la multirésistance aux médicaments | ||||||
| Termo(s) alternativo(s): |
ATP Binding Cassette, Sub Family C Proteins ATP-Binding Cassette, Sub-Family C Proteins MOAT Protein Multidrug Resistance Associated Protein Multidrug Resistance Associated Proteins Multidrug Resistance-Associated Protein Multispecific Organic Anion Transport Proteins Multispecific Organic Anion Transporter Resistance-Associated Protein, Multidrug |
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| Código(s) hierárquico(s): |
D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D027425 | ||||||
| Nota de escopo: | A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
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| Qualificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Indexação Anterior: |
P-Glycoprotein (1987-2001) |
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| Nota MeSH pública: | 2002; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN was indexed under ABC TRANSPORTERS 1994-2001; MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER were indexed under CARRIER PROTEINS 1995-2001 |
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| Nota histórica: | 2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001 |
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| Versão alternativa: | MULTIDRUG RESISTANCE ASSOC PROTEINS |
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| Veja também os descritores: |
ATP Binding Cassette Transporter, Subfamily B
MeSH Drug Resistance, Multiple MeSH | ||||||
| Identificador DeCS: | 36147 | ||||||
| ID do descritor: | D027425 | ||||||
| Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
| Data de estabelecimento: | 01/01/2002 | ||||||
| Data de entrada: | 25/07/2001 | ||||||
| Data de revisão: | 13/07/2018 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Multidrug Resistance-Associated Proteins
- Conceito preferido
| Identificador do conceito |
M0238823 |
| Nota de escopo | A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
| Termo preferido | Multidrug Resistance-Associated Proteins |
| Termo(s) alternativo(s) |
ATP Binding Cassette, Sub Family C Proteins ATP-Binding Cassette, Sub-Family C Proteins MOAT Protein Multidrug Resistance Associated Protein Multidrug Resistance Associated Proteins Multidrug Resistance-Associated Protein Multispecific Organic Anion Transport Proteins Multispecific Organic Anion Transporter Resistance-Associated Protein, Multidrug |
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