Visão selecionada em Inglês
Descritor em português: | Neuropilinas | ||||||
Descritor em inglês: | Neuropilins | ||||||
Descritor em espanhol: |
Neuropilinas
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Descritor em francês: | Neuropilines | ||||||
Termo(s) alternativo(s): |
Neuropilin |
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Código(s) hierárquico(s): |
D12.776.543.750.590 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D039921 | ||||||
Nota de escopo: | Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. |
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Qualificadores permitidos: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
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Indexação Anterior: |
Nerve Tissue Proteins (1998-2002) |
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Nota MeSH pública: | 2003; NEUROPILIN was indexed under NERVE TISSUE PROTEINS 1998-2002 |
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Nota histórica: | 2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002 |
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Identificador DeCS: | 37475 | ||||||
ID do descritor: | D039921 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/2003 | ||||||
Data de entrada: | 03/07/2002 | ||||||
Data de revisão: | 31/05/2016 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Neuropilins
- Conceito preferido
Identificador do conceito |
M0191838 |
Nota de escopo | Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. |
Termo preferido | Neuropilins |
Termo(s) alternativo(s) |
Neuropilin |
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