Pesquisa
Descritor em português: Endonucleases Flap
Descritor em inglês: Flap Endonucleases
Descritor em espanhol: Endonucleasas de ADN Solapado
Descritor endonucleasas de solapas del ADN
Termo(s) alternativo(s) FEN-1
endonucleasa de ADN solapado
endonucleasa flap 1
endonucleasas de ADN solapado
endonucleasas de cadena sobrepuesta del ADN
endonucleasas de secuencias solapadas
endonucleasas de solapas
endonucleasas flap
nucleasa RTH-1
nucleasa homóloga 1 de RAD2
proteína Fen1
Nota de escopo: Endonucleasas que eliminan secuencias nucleotídicas del extremo 5' de una estructura de ADN llamada "DNA flap" (dominio de ADN tricatenario). Dicha estructura se da en los ADN bicatenarios que contienen una interrupción en una de las cadenas, de modo que la porción 5' de la cadena anterior a la interrupción es demasiado larga y se solapa con el extremo 3' de la cadena posterior a la interrupción. Las endonucleasas flap escinden la cadena anterior de la estructura que contiene el solapamiento justo después del primer nucléotido apareado y con ello crean una muesca sellable.
Descritor em francês: Flap endonucleases
Termo(s) alternativo(s): Endonuclease-1, Flap
Endonucleases, Flap
FEN-1
Fen1 Protein
Flap Endonuclease
Flap Endonuclease 1
Flap Endonuclease-1
Nuclease, RTH-1
RAD2 Homolog 1 Nuclease
RAD2 Homolog-1 Nuclease
RTH 1 Nuclease
RTH-1 Nuclease
Código(s) hierárquico(s): D08.811.277.352.355.325.350
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D045585
Nota de escopo: Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: EC 3.1.-
Indexação Anterior: Endodeoxyribonucleases (1994-2003)
Nota MeSH pública: 2004; FLAP ENDONUCLEASES was indexed under ENDODEOYRIBONUCLEASES 1994-2003; FEN1 PROTEIN was indexed under EXODEOXYRIBNUCLEASES 1997-2003; RTH-1 NUCLEASE was indexed under EXODEOXYRIBNUCLEASES 1996-2003
Nota histórica: 2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003
Identificador DeCS: 38146
ID do descritor: D045585
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/2004
Data de entrada: 09/07/2003
Data de revisão: 24/05/2017
Flap Endonucleases - Conceito preferido
Identificador do conceito M0228928
Nota de escopo Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Termo preferido Flap Endonucleases
Termo(s) alternativo(s) Endonucleases, Flap
Flap Endonuclease
Flap Endonuclease-1 - Mais específico
Identificador do conceito M0448833
Termo preferido Flap Endonuclease-1
Termo(s) alternativo(s) Endonuclease-1, Flap
FEN-1
Fen1 Protein
Flap Endonuclease 1
Nuclease, RTH-1
RAD2 Homolog 1 Nuclease
RAD2 Homolog-1 Nuclease
RTH 1 Nuclease
RTH-1 Nuclease



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