Pesquisa
Descritor em português: Complexo de Endopeptidases do Proteassoma
Descritor em inglês: Proteasome Endopeptidase Complex
Descritor em espanhol: Complejo de la Endopetidasa Proteasomal
Descritor complejo de endopeptidasas de los proteasomas
Nota de escopo: Gran complejo con múltiples subunidades que desempeña una función importante en la degradación de la mayoría de las proteínas citosólicas y nucleares de células eucarióticas. Contiene un subcomplejo catalítico de 700 kDa y dos subcomplejos regulatorios de 700 kDa. El complejo digiere proteínas ubiquitinadas y proteínas activadas a través de la antienzima ornitina-descarboxilasa.
Descritor em francês: Proteasome endopeptidase complex
Termo(s) alternativo(s): 20S Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Ingensin
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Proteasome, 20S
Proteinase, Multicatalytic
Código(s) hierárquico(s): D05.500.562.500
D08.811.277.656.918
D08.811.600.730
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D046988
Nota de escopo: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Combinação de entrada: antagonists & inhibitors:Proteasome Inhibitors
Número de registro: EC 3.4.25.1
Indexação Anterior: Cysteine Endopeptidases (1986-2004)
Multienzyme Complexes (1986-2004)
Nota MeSH pública: 2005; PROTEASOME ENDOPEPTIDASE COMPLEX was indexed under CYSTEINE ENDOPEPTIDASES & MULTIENZYME COMPLEXES 1986-2004
Nota histórica: 2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
Veja também os descritores: Ubiquitin-Protein Ligase Complexes MeSH
Identificador DeCS: 38685
ID do descritor: D046988
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/2005
Data de entrada: 07/07/2004
Data de revisão: 03/07/2012
Proteasome Endopeptidase Complex - Conceito preferido
Identificador do conceito M0140424
Nota de escopo A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Termo preferido Proteasome Endopeptidase Complex
Termo(s) alternativo(s) 20S Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Proteasome, 20S
Proteinase, Multicatalytic
Ingensin - Mais específico
Identificador do conceito M0140417
Termo preferido Ingensin



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