Visão selecionada em Inglês
Descritor em português: | Perforina | ||||||
Descritor em inglês: | Perforin | ||||||
Descritor em espanhol: |
Perforina
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Descritor em francês: | Perforine | ||||||
Termo(s) alternativo(s): |
Cytolysin Lymphocyte Pore Forming Protein Lymphocyte Pore-Forming Protein Perforin 1 Pore-Forming Protein, Lymphocyte |
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Código(s) hierárquico(s): |
D12.776.543.695.875 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D054353 | ||||||
Nota de escopo: | A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell. |
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Qualificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Ação Farmacológica: |
Citotoxinas |
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Número de registro: | 126465-35-8 | ||||||
Indexação Anterior: |
Membrane Glycoproteins (1985-2007) Pore Forming Cytotoxic Proteins (1985-2007) |
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Nota MeSH pública: | 2008; PERFORIN was indexed under MEMBRANE GLYCOPROTEINS & PORE FORMING CYTOTOXIC PROTEINS 1985-2007 |
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Nota histórica: | 2008 |
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Identificador DeCS: | 52798 | ||||||
ID do descritor: | D054353 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/2008 | ||||||
Data de entrada: | 09/07/2007 | ||||||
Data de revisão: | 08/07/2008 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Perforin
- Conceito preferido
Identificador do conceito |
M0133732 |
Nota de escopo | A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell. |
Termo preferido | Perforin |
Termo(s) alternativo(s) |
Cytolysin Lymphocyte Pore Forming Protein Lymphocyte Pore-Forming Protein Perforin 1 Pore-Forming Protein, Lymphocyte |
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