Visão selecionada em Inglês
Descritor em português: | Separase | ||||
Descritor em inglês: | Separase | ||||
Descritor em espanhol: |
Separasa
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Descritor em francês: | Separase | ||||
Código(s) hierárquico(s): |
D08.811.277.656.262.500.792 D08.811.277.656.300.200.792 D12.776.167.552 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D064247 | ||||
Nota de escopo: | Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation. |
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Qualificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 3.4.22.49 | ||||
Indexação Anterior: |
Cell Cycle Proteins (1999-2013) Endopeptidases (1999-2013) |
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Nota MeSH pública: | 2014; was indexed under ENDOPEPTIDASES and CELL CYCLE PROTEINS 1999-2013 |
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Nota histórica: | 2014 |
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Identificador DeCS: | 55268 | ||||
ID do descritor: | D064247 | ||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||
Data de estabelecimento: | 01/01/2014 | ||||
Data de entrada: | 08/07/2013 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Separase
- Conceito preferido
Identificador do conceito |
M0580540 |
Nota de escopo | Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation. |
Termo preferido | Separase |
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