Pesquisa
Descritor em português: Alarminas
Descritor em inglês: Alarmins
Descritor em espanhol: Alarminas
Descritor alarminas
Termo(s) alternativo(s) alarmina
moléculas de patrones moleculares asociadas a daño
moléculas de patrones moleculares asociadas a peligro
Nota de escopo: Grupo estructuralmente diverso de moléculas endógenas multifuncionales, que tienen funciones fisiológicas dentro de la célula, pero que cuando son liberadas por células muertas o sometidas a estrés, o por ciertas células inmunitarias, activan la INMUNIDAD INNATA. La liberación incontrolada y excesiva de alarminas puede contribuir a la INFLAMACIÓN, la CARCINOGÉNESIS y las METÁSTASIS. Las alarminas también son cruciales para la homeostasis del corazón y del tejido nervioso.
Descritor em francês: Alarmines
Termo(s) alternativo(s): Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules
Código(s) hierárquico(s): D23.469.025
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D000067531
Nota de escopo: A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Indexação Anterior: HMGB1 Protein (2004-2015)
Nota MeSH pública: 2016
Nota histórica: 2016
Identificador DeCS: 55964
ID do descritor: D000067531
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/2016
Data de entrada: 01/07/2015
Data de revisão: 30/06/2016
Alarmins - Conceito preferido
Identificador do conceito M000599994
Nota de escopo A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Termo preferido Alarmins
Termo(s) alternativo(s) Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules



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