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Descritor em português: | Proteína 9 Associada à CRISPR | ||||||
Descritor em inglês: | CRISPR-Associated Protein 9 | ||||||
Descritor em espanhol: |
Proteína 9 Asociada a CRISPR
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Descritor em francês: | Protéine-9 associée à CRISPR | ||||||
Termo(s) alternativo(s): |
CRISPR Associated Protein 9 Cas9 Endonuclease Cas9 Enzyme Cas9 Protein Endonuclease, Cas9 Enzyme, Cas9 |
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Código(s) hierárquico(s): |
D08.811.277.352.355.325.150 D12.776.097.219 D12.776.212.500 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000076987 | ||||||
Nota de escopo: | An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. |
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Qualificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 3.1.- | ||||||
Indexação Anterior: |
Bacterial Proteins (2015-2018) Endonucleases (2015-2018) |
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Nota MeSH pública: | 2019 |
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Nota histórica: | 2019 |
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Veja também os descritores: |
CRISPR-Cas Systems
MeSH Gene Editing MeSH | ||||||
Identificador DeCS: | 57498 | ||||||
ID do descritor: | D000076987 | ||||||
Documentos indexados na Biblioteca Virtual em Saúde (BVS): | Clique aqui para acessar os documentos da BVS | ||||||
Data de estabelecimento: | 01/01/2019 | ||||||
Data de entrada: | 09/07/2018 | ||||||
Data de revisão: | 15/06/2018 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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CRISPR-Associated Protein 9
- Conceito preferido
Identificador do conceito |
M000638955 |
Nota de escopo | An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. |
Termo preferido | CRISPR-Associated Protein 9 |
Termo(s) alternativo(s) |
CRISPR Associated Protein 9 Cas9 Endonuclease Cas9 Enzyme Cas9 Protein Endonuclease, Cas9 Enzyme, Cas9 |
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