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Descritor em português: Diversidade de Anticorpos
Descritor em inglês: Antibody Diversity
Descritor em espanhol: Diversidad de Anticuerpos
Descritor diversidad de anticuerpos
Termo(s) alternativo(s) teoría de la línea germinal
Nota de escopo: El fenómeno de la inmensa variabilidad característica de los ANTICUERPOS. Esto posibilita que el SISTEMA INMUNOLÓGICO reaccione específicamente frente a tipos esencialmente ilimitados de ANTÍGENOS. La diversidad de los anticuerpos se explica por tres teorías principales: (1) la Teoría de la línea germinal, que sostiene que cada célula productora de anticuerpo posee genes que codifican todos los posibles anticuerpos pero expresan solo el estimulado por el antígeno, (2) la Teoría de la mutación somática según la cual las células productoras de anticuerpos contienen solo unos pocos genes que producen diversidad de anticuerpos mediante mutación, y la (3) Teoría del reordenamiento génico, según la cual la diversidad de los anticuerpos se genera mediante el reordenamiento de segmentos del gen de la REGIÓN VARIABLE DE INMUNOGLOBULINAS durante la diferenciación de las CÉLULAS PRODUCTORAS DE ANTICUERPOS.
Descritor em francês: Diversité des anticorps
Termo(s) alternativo(s): Antibody Diversities
Diversities, Antibody
Diversity, Antibody
Germ Line Theories
Germ Line Theory
Theories, Germ Line
Theory, Germ Line
Código(s) hierárquico(s): G05.365.036
G12.500.199
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D000916
Nota de escopo: The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Qualificadores permitidos: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Indexação Anterior: Antibodies (1966-1969)
Antibody Specificity (1970-1979)
Nota MeSH pública: 80
Nota histórica: 80
Identificador DeCS: 926
ID do descritor: D000916
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1980
Data de entrada: 23/02/1979
Data de revisão: 22/06/2015
Antibody Diversity - Conceito preferido
Identificador do conceito M0001364
Nota de escopo The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Termo preferido Antibody Diversity
Termo(s) alternativo(s) Antibody Diversities
Diversities, Antibody
Diversity, Antibody
Germ Line Theory - Mais específico
Identificador do conceito M0001365
Termo preferido Germ Line Theory
Termo(s) alternativo(s) Germ Line Theories
Theories, Germ Line
Theory, Germ Line



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