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Descriptor en español: |
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
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Descriptor en inglés: | 11-beta-Hydroxysteroid Dehydrogenase Type 2 | ||||
Descriptor en portugués: | 11-beta-Hidroxiesteroide Desidrogenase Tipo 2 | ||||
Descriptor en francés: | 11-beta-Hydroxysteroid dehydrogenase type 2 | ||||
Término(s) alternativo(s): |
11 beta Hydroxysteroid Dehydrogenase Type 2 11 beta-HSD2 11 beta-Hydroxysteroid Dehydrogenase Type 2 11beta Hydroxysteroid Dehydrogenase Type 2 11beta-HSD2 11beta-HSD2 Reductase 11beta-Hydroxysteroid Dehydrogenase Type 2 |
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Código(s) jeráquico(s): |
D08.811.682.047.436.174.600 D08.811.682.047.820.100.600 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D043209 | ||||
Nota de alcance: | An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Combinación alternativa: |
deficiency:Mineralocorticoid Excess Syndrome, Apparent
deficiencia:Síndrome de Exceso Aparente de Mineralocorticoides deficiência:Síndrome de Excesso Aparente de Minerolocorticoides |
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Número de registro: | EC 1.1.1.146 | ||||
Indexación anterior: |
Hydroxysteroid Dehydrogenases (1992-2003) |
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Nota Pública de MeSH: | 2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003 |
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Nota de historia: | 2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003 |
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Identificador de DeCS: | 38200 | ||||
ID del Descriptor: | D043209 | ||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||
Fecha de establecimiento: | 01/01/2004 | ||||
Fecha de entrada: | 09/07/2003 | ||||
Fecha de revisión: | 08/07/2013 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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11-beta-Hydroxysteroid Dehydrogenase Type 2
- Concepto preferido
UI del concepto |
M0076299 |
Nota de alcance | An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. |
Término preferido | 11-beta-Hydroxysteroid Dehydrogenase Type 2 |
Término(s) alternativo(s) |
11 beta Hydroxysteroid Dehydrogenase Type 2 11 beta-HSD2 11 beta-Hydroxysteroid Dehydrogenase Type 2 11beta Hydroxysteroid Dehydrogenase Type 2 11beta-HSD2 11beta-HSD2 Reductase 11beta-Hydroxysteroid Dehydrogenase Type 2 |
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