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Descriptor en español: |
Espastina
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Descriptor en inglés: | Spastin | ||||||
Descriptor en portugués: | Espastina | ||||||
Descriptor en francés: | Spastine | ||||||
Término(s) alternativo(s): |
Spastic Paraplegia 4 Protein |
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Código(s) jeráquico(s): |
D08.811.277.040.013.500.500 D08.811.277.040.025.024.500 D12.776.157.025.750.500 D12.776.220.600.450.465 D12.776.631.560.480 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000074181 | ||||||
Nota de alcance: | An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA. |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 3.6.4.3 | ||||||
Indexación anterior: |
Adenosine Triphosphatases (1999-2017) |
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Nota Pública de MeSH: | 2018 |
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Nota de historia: | 2018 |
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Vea también los descriptores: |
AAA Domain
MeSH | ||||||
Identificador de DeCS: | 56995 | ||||||
ID del Descriptor: | D000074181 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/2018 | ||||||
Fecha de entrada: | 11/07/2017 | ||||||
Fecha de revisión: | 01/03/2017 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Spastin
- Concepto preferido
UI del concepto |
M000625779 |
Nota de alcance | An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA. |
Término preferido | Spastin |
Término(s) alternativo(s) |
Spastic Paraplegia 4 Protein |
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