DeCS

Descritor em português:

Enzima de Clivagem da Cadeia Lateral do Colesterol

Descritor em inglês:

Cholesterol Side-Chain Cleavage Enzyme

Descritor em espanhol:

Enzima de Desdoblamiento de la Cadena Lateral del Colesterol

Espanhol da Espanha

Descritor	enzima de escisión de la cadena lateral del colesterol
Termo(s) alternativo(s)	CIP11A1 citocromo P-450 CIP11A1 citocromo P-450(scc) colesterol 20-22 desmolasa colesterol desmolasa colesterol monooxigenasa (desdoblamiento de la cadena lateral) esteroide 20-22-desmolasa esteroide 20-22-liasa
Nota de escopo:	Enzima del citocromo P450 mitocondrial que cataliza la escisión de la cadena lateral del colesterol C27 en pregnenolona C21 en presencia de oxígeno molecular y de NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por el gen CYP11A1, cataliza la escisión entre C20 y C22, que es el paso inicial y limitante de la biosíntesis de diversas hormonas esteroides gonadales y suprarrenales.

Descritor em francês:

Cholesterol side-chain cleavage enzyme

Termo(s) alternativo(s):

20,22 Desmolase
20,22-Desmolase
CYP 11A1
CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cholesterol Side Chain Cleavage Enzyme
Cytochrome P 450 CYP11A1
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
Cytochrome P450 11A1
Cytochrome P450scc

Código(s) hierárquico(s):

D08.244.453.484.250
D08.244.453.915.212
D08.811.682.690.708.170.425.250
D08.811.682.690.708.170.915.212
D12.776.422.220.453.484.250
D12.776.422.220.453.915.212

Identificador Único RDF:

https://id.nlm.nih.gov/mesh/D002786

Nota de escopo:

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.

Qualificadores permitidos:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Identificador do conceito	M0004271
Nota de escopo	A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Termo preferido	Cholesterol Side-Chain Cleavage Enzyme
Termo(s) alternativo(s)	20,22 Desmolase 20,22-Desmolase CYP 11A1 CYP11A1 Cholesterol Desmolase Cholesterol Monooxygenase (Side-Chain-Cleaving) Cholesterol Side Chain Cleavage Enzyme Cytochrome P 450 CYP11A1 Cytochrome P-450 CYP11A1 Cytochrome P-450(scc) Cytochrome P450 11A1 Cytochrome P450scc

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