DeCS

Descritor em português:

Transglutaminases

Descritor em inglês:

Transglutaminases

Descritor em espanhol:

Transglutaminasas

Espanhol da Espanha

Descritor	transglutaminasas
Termo(s) alternativo(s)	glutaminil-péptido gammaglutamiltransferasas proteína-glutamina gammaglutamiltransferasas transglutaminasa
Nota de escopo:	Enzimas que catalizan el enlace cruzado de proteínas a una glutamina en una cadena y a LISINA en otra cadena. Comprenden la transglutaminasa de los queratinocitos (TGM1 o TGK), la transglutaminasa tisular (TGM2 o TGC), la transglutaminasa plasmática implicada en la coagulación (FACTOR XIII y FACTOR XIIIa), la transglutaminasa del folículo piloso y la transglutaminasa prostática. Aunque tienen diferentes estructuras comparten un sitio activo (YGQCW) y la estricta dependencia del CALCIO.

Descritor em francês:

Transglutaminases

Termo(s) alternativo(s):

Glutaminyl-peptide gamma-glutamyltransférases

Código(s) hierárquico(s):

D08.811.913.050.200.800

Identificador Único RDF:

https://id.nlm.nih.gov/mesh/D011503

Nota de escopo:

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Nota de indexação:

distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available

Qualificadores permitidos:

AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine

Número de registro:

EC 2.3.2.13

Nome CAS Tipo 1:

Protein-glutamine:amine gamma-glutamyltransferase

Identificador DeCS:

27787

ID do descritor:

D011503

Documentos indexados na Biblioteca Virtual em Saúde (BVS):

Clique aqui para acessar os documentos da BVS

Data de estabelecimento:

01/01/1986