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Descriptor English: Transglutaminases
Descriptor Spanish: Transglutaminasas
Descriptor Portuguese: Transglutaminases
Descriptor French: Transglutaminases
Entry term(s): Gamma-Glutamyltransferases, Glutaminyl-Peptide
Glutaminyl Peptide Gamma Glutamyltransferases
Glutaminyl-Peptide Gamma-Glutamyltransferases
Protein Glutamine gamma Glutamyltransferases
Protein-Glutamine gamma-Glutamyltransferases
Transglutaminase
gamma-Glutamyltransferases, Protein-Glutamine
Tree number(s): D08.811.913.050.200.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011503
Scope note: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Annotation: distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.2.13
CAS Type 1 Name: Protein-glutamine:amine gamma-glutamyltransferase
Previous Indexing: Acyltransferases (1966-1985)
Public MeSH Note: 2002; see PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 1986-2002; for TRANSGLUTAMINASES see TRANSGLUTAMINASES 1986-2002
History Note: 2002(1986)
DeCS ID: 27787
Unique ID: D011503
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/04/24
Revision Date: 2020/05/27
Transglutaminases - Preferred
Concept UI M0017884
Scope note Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Preferred term Transglutaminases
Entry term(s) Gamma-Glutamyltransferases, Glutaminyl-Peptide
Glutaminyl Peptide Gamma Glutamyltransferases
Glutaminyl-Peptide Gamma-Glutamyltransferases
Protein Glutamine gamma Glutamyltransferases
Protein-Glutamine gamma-Glutamyltransferases
Transglutaminase
gamma-Glutamyltransferases, Protein-Glutamine



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