DeCS

Descritor em português:

Serina Peptidase 2 de Requerimento de Alta Temperatura A

Descritor em inglês:

High-Temperature Requirement A Serine Peptidase 2

Descritor em espanhol:

Serina Peptidasa A2 que Requiere Temperaturas Altas

Espanhol da Espanha

Descritor	serina peptidasa A2 que requiere temperaturas altas
Termo(s) alternativo(s)	proteasa HtrA2 serina peptidasa HtrA2 serina protease Omi
Nota de escopo:	Serina peptidasa que contiene un dominio PDZ carboxiterminal. Se localiza en la membrana y el espacio intermembranoso mitocondrial y se transloca al citoplasma en respuesta a estímulos de la APOPTOSIS como la irradiación UV; promueve la muerte celular por unión e inhibición de las PROTEÍNAS INHIBIDORAS DE LA APOPTOSIS, lo que da lugar a un incremento de la actividad de las CASPASAS. Las mutaciones del gen HTRA2 se asocian a algunas formas de la ENFERMEDAD DE PARKINSON (PARK13).

Descritor em francês:

High-temperature requirement A serine peptidase 2

Termo(s) alternativo(s):

HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease HTRA2
Serine Protease Omi
Serine Protease, Omi

Código(s) hierárquico(s):

D08.811.277.656.300.760.431
D08.811.277.656.959.350.431
D12.776.476.075.429
D12.776.575.656
D12.776.705.625

Identificador Único RDF:

https://id.nlm.nih.gov/mesh/D000074923

Nota de escopo:

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

Qualificadores permitidos:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Identificador do conceito	M000628721
Nota de escopo	A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Termo preferido	High-Temperature Requirement A Serine Peptidase 2
Termo(s) alternativo(s)	HTRA2, Serine Protease High Temperature Requirement A Serine Peptidase 2 HtrA Serine Peptidase 2 HtrA2 Protease Omi Serine Protease Omi, Serine Protease Protease HTRA2, Serine Protease Omi, Serine Protease, HtrA2 Protease, Omi Serine Serine Protease HTRA2 Serine Protease Omi Serine Protease, Omi

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