Pesquisa
Descritor em português: Receptor de Pregnano X
Descritor em inglês: Pregnane X Receptor
Descritor em espanhol: Receptor X de Pregnano
Descritor receptor X de pregnano
Termo(s) alternativo(s) NR1I2
miembro 2 del grupo I de la subfamilia 1 de receptores nucleares
receptor SXR
receptor X de esteroides
receptor de esteroides y xenobióticos
Nota de escopo: Receptor esteroideo que se une a diversos compuestos endógenos y XENOBIÓTICOS y que es activado por ellos. Se une al elemento de respuesta en los promotores de genes que codifican las proteínas del CITOCROMO P-450, miembro CYP3A4, y del TRANSPORTADOR DE CASETES DE UNIÓN AL ATP, SUBFAMILIA B, MIEMBRO 1, y activa también la transcripción de diversos genes que intervienen en el metabolismo y en la secreción de fármacos, compuestos endógenos y xenobióticos potencialmente nocivos. Es activado por el antibiótico RIFAMPICINA y por diversos metabolitos vegetales, tales como la hiperforina, el gugulípido, la colupulona y las ISOFLAVONAS.
Descritor em francês: Récepteur du prégnane X
Termo(s) alternativo(s): NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor
Código(s) hierárquico(s): D12.776.826.750.075
D12.776.930.778.175
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D000077297
Nota de escopo: Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Qualificadores permitidos: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Nota MeSH pública: 2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
Nota histórica: 2019 (1998)
Identificador DeCS: 57597
ID do descritor: D000077297
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/2019
Data de entrada: 09/07/2018
Data de revisão: 28/02/2018
Pregnane X Receptor - Conceito preferido
Identificador do conceito M0287170
Nota de escopo Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Termo preferido Pregnane X Receptor
Termo(s) alternativo(s) NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor



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