Pesquisa sobre: MFN=57081 
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Descritor Inglês:   Bestrophins 
Descritor Espanhol:   Bestrofinas 
Descritor Português:   Bestrofinas 
Sinônimos Inglês:   BEST-1 Protein
BEST-2 Protein
Bestrophin Family
Bestrophin Proteins
Bestrophin-1
Bestrophin-2
BEST 1 Protein
BEST 2 Protein
Bestrophin 1
Bestrophin 2  
Categoria:   D12.776.157.530.400.175.063
D12.776.306.228
D12.776.543.550.450.175.063
D12.776.543.585.400.175.063
Definição Inglês:   A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57081 
Identificador Único:   D000075002 

Ocorrência na BVS:
 
MEDLINE    

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