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Descriptor English: Loss of Heterozygosity
Descriptor Spanish: Pérdida de Heterocigocidad
Descriptor pérdida de heterocigosidad
Entry term(s) pérdida alélica
Scope note: Pérdida de un alelo en un locus específico, causada por deleción o por pérdida de uno de los cromosomas de un par, resultando una HEMICIGOSIDAD anormal. Se detecta cuando los marcadores heterozigósicos de un locus dan un resultado monomorfo porque falta uno de los ALELOS.
Descriptor Portuguese: Perda de Heterozigosidade
Descriptor French: Perte d'hétérozygotie
Entry term(s): Allelic Loss
Allelic Losses
Heterozygosity Loss
Heterozygosity, Loss of
Tree number(s): G05.365.590.029.530
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019656
Scope note: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Annotation: do not confuse entry term ALLELIC LOSS with ALLELIC IMBALANCE
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Chromosome Deletion (1987-1997)
Heterozygote (1983-1997)
Public MeSH Note: 98
History Note: 98
Related: Hemizygote MeSH
DeCS ID: 33610
Unique ID: D019656
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/07/14
Revision Date: 2010/06/25
Loss of Heterozygosity - Preferred
Concept UI M0029159
Scope note The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Preferred term Loss of Heterozygosity
Entry term(s) Allelic Loss
Allelic Losses
Heterozygosity Loss
Heterozygosity, Loss of



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