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Descriptor English: Cleavage Stimulation Factor
Descriptor Spanish: Factor de Estimulación del Desdoblamiento
Descriptor factor de estimulación de la escisión
Entry term(s) factor de estimulación de desdoblamiento
Scope note: Proteína de unión al ARN que estimula la escisión del extremo 3' del ARNm cerca del sitio de POLIADENILACIÓN. Es un heterotrímero de subunidades de 55, 64 y 77 kD y se combina con el FACTOR DE ESTIMULACIÓN DE DESDOBLAMIENTO formando un complejo estable con el ARNm que dirige la separación en 3' y la reacción de poliadenilación. .
Descriptor Portuguese: Fator Estimulador de Clivagem
Descriptor French: Facteur de stimulation du clivage
Entry term(s): CstF Protein
Tree number(s): D12.776.157.725.124.249
D12.776.664.962.444.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039241
Scope note: A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa subunits and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA-Binding Proteins (1992-2002)
Public MeSH Note: 2003; CLEAVAGE STIMULATION FACTOR was indexed under RNA-BINDING PROTEINS 1992-2002
History Note: 2003; for CLEAVAGE STIMULATION FACTOR use MRNA CLEAVAGE AND POLYADENYLATION FACTORS (NM) 1992-2002
DeCS ID: 37404
Unique ID: D039241
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09
Cleavage Stimulation Factor - Preferred
Concept UI M0195405
Scope note A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa subunits and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Preferred term Cleavage Stimulation Factor
Entry term(s) CstF Protein



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