Descriptor English: | Lopinavir | ||||
Descriptor Spanish: |
Lopinavir
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Descriptor Portuguese: | Lopinavir | ||||
Descriptor French: | Lopinavir | ||||
Entry term(s): |
A 157378.0 A-157378.0 A157378.0 ABT 378 ABT-378 ABT378 N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide |
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Tree number(s): |
D03.383.742.698.553 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D061466 | ||||
Scope note: | An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A. |
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Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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Pharm Action: |
HIV Protease Inhibitors Cytochrome P-450 CYP3A Inhibitors |
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Registry Number: | 2494G1JF75 | ||||
Public MeSH Note: | 2012; LOPNAVIR was indexed under PYRIMIDINONES 2000-2011 |
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History Note: | 2012 |
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DeCS ID: | 54552 | ||||
Unique ID: | D061466 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 2012/01/01 | ||||
Date of Entry: | 2011/06/27 | ||||
Revision Date: | 2016/07/01 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
|
Lopinavir
- Preferred
A-157378.0
- Narrower
ABT 378
- Narrower
Concept UI |
M0558541 |
Scope note | An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A. |
Preferred term | Lopinavir |
Entry term(s) |
N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide |
Concept UI |
M0406971 |
Preferred term | A-157378.0 |
Entry term(s) |
A 157378.0 A157378.0 |
Concept UI |
M0289886 |
Preferred term | ABT 378 |
Entry term(s) |
ABT-378 ABT378 |
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