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Descriptor English: Keratins
Descriptor Spanish: Queratinas
Descriptor queratinas
Entry term(s) citoqueratina
proteína asociada a la queratina
Scope note: Clase de proteínas fibrosas o escleroproteínas que son el principal componente de la EPIDERMIS, el PELO, las UÑAS, los tejidos córneos y la matriz orgánica del ESMALTE dental. Se han identificado dos grupos conformacionales: la alfa-queratina, cuyo esqueleto peptídico constituye una estructura formada por dos hélices alfa paralelas enrolladas entre sí que conforma la QUERATINA DE TIPO I y la QUERATINA DE TIPO II; y la beta-queratina, cuyo esqueleto constituye una estructura en zigzag o en forma de hoja plegada. Las alfa-queratinas se han clasificado en al menos 20 subtipos. Ademas, debido a la DUPLICACIÓN GÉNICA, se han encontrado múltiples isoformas de los subtipos.
Descriptor Portuguese: Queratinas
Descriptor French: Kératines
Entry term(s): Cytokératines
Kératine-alpha
Kératines glycosylées
Protéines associées à la kératine
alpha-Kératine
Tree number(s): D05.750.078.593.450
D12.776.220.475.450
D12.776.860.607
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007633
Scope note: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: 68238-35-7
Related: Filaments intermédiaires MeSH
Kératinocytes MeSH
DeCS ID: 7802
Unique ID: D007633
NLM Classification: QU 55.3
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Kératines - Preferred
Concept UI M0011957
Preferred term Kératines
Entry term(s) Cytokératines
Kératines glycosylées - Narrower
Concept UI M0143311
Preferred term Kératines glycosylées
Protéines associées à la kératine - Narrower
Concept UI M0213667
Preferred term Protéines associées à la kératine
alpha-Kératine - Narrower
Concept UI M0494274
Preferred term alpha-Kératine
Entry term(s) Kératine-alpha



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