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Descriptor English: Neuropilin-2
Descriptor Spanish: Neuropilina-2
Descriptor neuropilina-2
Scope note: Receptor transmembranario de las SEMAFORINAS CLASE 3 y algunas isoformas del factor de crecimiento del endotelio vascular. La neuropilina-2 funciona como homodímero o como heterodímero con la NEUROPILINA-1. La afinidad de unión de la neuropilina-2 varía según las diferentes clases de isoformas de semaforina clase 3, y depende de la composición del dímero. Esta proteína forma también complejos receptores con las plexinas y con los RECEPTORES VEGF, lo que altera las características de unión del receptor.
Descriptor Portuguese: Neuropilina-2
Descriptor French: Neuropiline 2
Entry term(s): NRP2 Protein
Neuropilin 2
Npn 2 Protein
Npn-2 Protein
Tree number(s): D12.776.543.750.590.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039943
Scope note: Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Nerve Tissue Proteins (1998-2002)
Public MeSH Note: 2003; NPN-2 PROTEIN was indexed under NERVE TISSUE PROTEINS 1998-2002
History Note: 2003; for NPN-2 PROTEIN use NEUROPILIN-1 1998-2002
DeCS ID: 37477
Unique ID: D039943
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/05/31
Neuropilin-2 - Preferred
Concept UI M0377884
Scope note Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
Preferred term Neuropilin-2
Entry term(s) NRP2 Protein
Neuropilin 2
Npn 2 Protein
Npn-2 Protein



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