Search
Descriptor English: Neuropilin-1
Descriptor Spanish: Neuropilina-1
Descriptor neuropilina-1
Scope note: Receptor dimérico de la superficie celular implicado en la angiogénesis (NEOVASCULARIZACIÓN FISIOLÓGICA) y en la GUÍA AXONAL. La neuropilina-1 es una proteína transmembranaria de 140 kDa que se une a las SEMAFORINAS DE CLASE 3 y a varios otros factores de crecimiento. La neuropilina-1 forma complejos con plexinas o RECEPTORES DE VEGF; su afinidad de unión y especificidad están determinadas por la composición del dímero de neuropilina y la identidad de otros receptores que forman complejos con ella. La neuropilina-1 se expresa en distintos patrones durante el desarrollo neural, complementarios a los descritos para NEUROPILINA-2.
Descriptor Portuguese: Neuropilina-1
Descriptor French: Neuropiline 1
Entry term(s): A5 Antigen
Antigen, A5
NRP1 Protein
Neuropilin 1
Npn 1 Protein
Npn-1 Protein
Receptor, Sema III
Sema III Receptor
Semaphorin III Receptor
Tree number(s): D12.776.543.750.590.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039942
Scope note: A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Registry Number: 144713-63-3
Previous Indexing: Nerve Tissue Proteins (1991-2002)
Public MeSH Note: 2003; A5 ANTIGEN (now NEUROPILIN-1) was indexed under NERVE TISSUE PROTEINS 1991-2002
History Note: 2003; use NEUROPILIN-1 (NM) 1991-2002
DeCS ID: 37476
Unique ID: D039942
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/07/05
Neuropilin-1 - Preferred
Concept UI M0191842
Scope note A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Preferred term Neuropilin-1
Entry term(s) A5 Antigen
Antigen, A5
NRP1 Protein
Neuropilin 1
Npn 1 Protein
Npn-1 Protein
Receptor, Sema III
Sema III Receptor
Semaphorin III Receptor



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey