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Descriptor en español: |
Sistema de Señalización de MAP Quinasas
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Descriptor en inglés: | MAP Kinase Signaling System | ||||||
Descriptor en portugués: | Sistema de Sinalização das MAP Quinases | ||||||
Descriptor en francés: | Système de signalisation des MAP kinases | ||||||
Término(s) alternativo(s): |
Cascade, MAP Kinase ERK Pathway ERK Pathways ERK Signal Tranduction Pathway ERK1 2 Pathway ERK1 and ERK2 Pathway ERK1-2 Pathway ERK1-2 Pathways JNK Pathway JNK Pathways JNK Signaling Pathway JNK Signaling Pathways Kinase Cascade, MAP Kinase Pathway, p38 Kinase Pathways, p38 MAP Kinase Cascade MAP Kinase Cascades MAP Kinase Module MAP Kinase Modules MAP Kinase Signaling Cascade MAP Kinase Signaling Cascades MAP Kinase Signaling Pathway MAP Kinase Signaling Pathways MEK ERK Pathway MEK-ERK Pathway MEK-ERK Pathways Module, MAP Kinase Pathway, ERK Pathway, ERK1-2 Pathway, JNK Pathway, JNK Signaling Pathway, MEK-ERK Pathway, p38 Kinase Pathways, ERK Pathways, ERK1-2 Pathways, JNK Pathways, JNK Signaling Pathways, MEK-ERK Pathways, p38 Kinase Signaling Pathway, JNK Signaling Pathways, JNK p38 Kinase Pathway p38 Kinase Pathways p38 Kinase Signaling Pathway |
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Código(s) jeráquico(s): |
G02.111.820.560 G03.493.560 G04.835.560 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D020935 | ||||||
Nota de alcance: | An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. |
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Calificadores permitidos: |
DE drug effects GE genetics IM immunology PH physiology RE radiation effects |
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Indexación anterior: |
Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999) Protein Kinases (1989-1999) Protein-Serine-Threonine Kinases (1993-1999) Protein-Tyrosine Kinase (1989-1999) |
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Nota Pública de MeSH: | 2000 |
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Nota de historia: | 2000 |
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Vea también los descriptores: |
MAP Kinase Kinase Kinases
MeSH Mitogen-Activated Protein Kinase Kinases MeSH Mitogen-Activated Protein Kinases MeSH | ||||||
Identificador de DeCS: | 34468 | ||||||
ID del Descriptor: | D020935 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/2000 | ||||||
Fecha de entrada: | 05/11/1999 | ||||||
Fecha de revisión: | 23/06/2016 |
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PHENOMENA AND PROCESSES
Chemical Phenomena [G02]Chemical Phenomena -
PHENOMENA AND PROCESSES
Metabolism [G03]Metabolism -
PHENOMENA AND PROCESSES
Cell Physiological Phenomena [G04]Cell Physiological Phenomena
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MAP Kinase Signaling System
- Concepto preferido
ERK1-2 Pathway
- Relacionado pero no más amplio ni más estrecho
p38 Kinase Pathway
- Más estrecho
MAP Kinase Cascade
- Más estrecho
MAP Kinase Signaling Pathways
- Relacionado pero no más amplio ni más estrecho
MEK-ERK Pathway
- Más estrecho
ERK Signal Tranduction Pathway
- Más estrecho
JNK Pathway
- Más estrecho
UI del concepto |
M0328035 |
Nota de alcance | An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. |
Término preferido | MAP Kinase Signaling System |
UI del concepto |
M0555312 |
Término preferido | ERK1-2 Pathway |
Término(s) alternativo(s) |
ERK1 2 Pathway ERK1 and ERK2 Pathway ERK1-2 Pathways Pathway, ERK1-2 Pathways, ERK1-2 |
UI del concepto |
M0557375 |
Término preferido | p38 Kinase Pathway |
Término(s) alternativo(s) |
Kinase Pathway, p38 Kinase Pathways, p38 Pathway, p38 Kinase Pathways, p38 Kinase p38 Kinase Pathways p38 Kinase Signaling Pathway |
UI del concepto |
M0331442 |
Término preferido | MAP Kinase Cascade |
Término(s) alternativo(s) |
Cascade, MAP Kinase Kinase Cascade, MAP MAP Kinase Cascades MAP Kinase Module MAP Kinase Modules MAP Kinase Signaling Cascade MAP Kinase Signaling Cascades Module, MAP Kinase |
UI del concepto |
M0331445 |
Término preferido | MAP Kinase Signaling Pathways |
Término(s) alternativo(s) |
MAP Kinase Signaling Pathway |
UI del concepto |
M0556022 |
Término preferido | MEK-ERK Pathway |
Término(s) alternativo(s) |
MEK ERK Pathway MEK-ERK Pathways Pathway, MEK-ERK Pathways, MEK-ERK |
UI del concepto |
M0556021 |
Término preferido | ERK Signal Tranduction Pathway |
Término(s) alternativo(s) |
ERK Pathway ERK Pathways Pathway, ERK Pathways, ERK |
UI del concepto |
M0557374 |
Término preferido | JNK Pathway |
Término(s) alternativo(s) |
JNK Pathways JNK Signaling Pathway JNK Signaling Pathways Pathway, JNK Pathway, JNK Signaling Pathways, JNK Pathways, JNK Signaling Signaling Pathway, JNK Signaling Pathways, JNK |
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