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| Descriptor en español: |
Proteína Desglicasa DJ-1
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| Descriptor en inglés: | Protein Deglycase DJ-1 | ||||||
| Descriptor en portugués: | Proteína Desglicase DJ-1 | ||||||
| Descriptor en francés: | Protein deglycase DJ-1 | ||||||
| Término(s) alternativo(s): |
DJ 1 PARK7 Protein DJ 1 Protein DJ-1 Protein DJ-1, Protein Deglycase DJ-1-PARK7 Protein DJ1 Protein Deglycase, Parkinsonism Associated PARK7 Protein Parkinson Protein 7 Parkinsonism Associated Deglycase |
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| Código(s) jeráquico(s): |
D08.811.277.785 D12.776.705.875 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000071617 | ||||||
| Nota de alcance: | A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE. |
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| Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Número de registro: | EC 3.1.2.- | ||||||
| Indexación anterior: |
Intracellular Signaling Peptides and Proteins (1997-2016) Oncogene Proteins (1997-2016) |
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| Nota Pública de MeSH: | 2017 |
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| Nota de historia: | 2017 |
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| Identificador de DeCS: | 56493 | ||||||
| ID del Descriptor: | D000071617 | ||||||
| Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
| Fecha de establecimiento: | 01/01/2017 | ||||||
| Fecha de entrada: | 08/07/2016 | ||||||
| Fecha de revisión: | 15/04/2016 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Protein Deglycase DJ-1
- Concepto preferido
| UI del concepto |
M000615251 |
| Nota de alcance | A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE. |
| Término preferido | Protein Deglycase DJ-1 |
| Término(s) alternativo(s) |
DJ 1 PARK7 Protein DJ 1 Protein DJ-1 Protein DJ-1, Protein Deglycase DJ-1-PARK7 Protein DJ1 Protein Deglycase, Parkinsonism Associated PARK7 Protein Parkinson Protein 7 Parkinsonism Associated Deglycase |
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