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Descripteur en français: Proinsuline
Descripteur en anglais: Proinsulin
Descripteur en espagnol: Proinsulina
Descripteur proinsulina
Note d'application: Polipéptido pancreático de unos 110 aminoácidos, dependiendo de las especies, que es el precursor de la insulina. La proinsulina es producida por las CÉLULAS BETA PANCREÁTICAS y consta secuencialmente de la cadena N-terminal B, el péptido C de conexión, que puede escindirse mediante proteólisis, y la cadena C-terminal A. También contiene tres enlaces disulfuro, dos de ellos entre la cadena A y la cadena B. Después de la escisión en dos lugares, los productos secretados son la insulina y el péptido C. También se secreta en pequeñas cantidades proinsulina intacta, cuya bioactividad es escasa.
Descripteur en portugais: Proinsulina
Code(s) d'arborescence: D06.472.699.587.200.500
D12.644.548.586.200.500
D12.776.811.706
Identificateur unique RDF: https://id.nlm.nih.gov/mesh/D011384
Note d'application: A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Qualificatifs autorisés: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Numéro de registre: 9035-68-1
Nom CAS Type 1: Proinsulin
Indexation précédente: Insulin (1966-1971)
Note publique MeSH: 72
Note historique: 72
Identifiant DeCS: 11816
ID du Descripteur: D011384
Classification de la NLM: WK 820
Documents indexés dans la Biblioteque Virtuelle de Santé (BVS): Cliquez ici pour accéder aux documents VHL
Date d'établissement: 01/01/1972
Date d'entrée: 01/01/1999
Date de révision: 24/06/2011
Proinsulin - Concept préféré
Concept UI M0017685
Note d'application A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Terme préféré Proinsulin



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