Pesquisa
Descritor em português: Príons
Descritor em inglês: Prions
Descritor em espanhol: Priones
Descritor priones
Termo(s) alternativo(s) prion
proteínas de priones
virus de la encefalopatía del visón
Nota de escopo: Pequeñas partículas infecciosas proteináceas que resisten la inactivación por procedimientos que modifican los ÁCIDOS NUCLEICOS y que contienen una isoforma anormal de una proteína celular que es un componente importante y necesario. La isoforma anormal (precursora) es PrPSc (PROTEÍNAS PRPSC) y la isoforma celular PrPC (PROTEÍNAS PRPC). La secuencia primaria de aminoácidos de las dos isoformas es idéntica. Entre las enfermedades humanas producidas por priones se encuentran el SÍNDROME DE CREUTZFELDT-JAKOB, la ENFERMEDAD DE GERSTMANN-STRAUSSLER-SCHEINKER y el INSOMNIO FAMILIAR MORTAL.
Descritor em francês: Prions
Termo(s) alternativo(s): Encephalopathy Virus, Mink
Mink Encephalopathy Virus
Prion
Código(s) hierárquico(s): D12.776.785
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D011328
Nota de escopo: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
PY pathogenicity
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Indexação Anterior: PrPSc Proteins (1966-1985)
Viral Proteins (1966-1985)
Nota MeSH pública: 86; MINK ENCEPHALOPATHY VIRUS was heading 1991-92, was see under VERTEBRATE VIRUSES, UNCLASSIFIED (now VIRUSES, UNCLASSIFIED) 1975-90; TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK was see MINK ENCEPHALOPATHY VIRUS 1975-92
Nota Online: use PRIONS to search MINK ENCEPHALOPATHY VIRUS & TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK 1975-92
Nota histórica: 86; MINK ENCEPHALOPATHY VIRUS was heading 1991-92, was see under VERTEBRATE VIRUSES, UNCLASSIFIED (now VIRUSES, UNCLASSIFIED) 1975-90; TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK was see MINK ENCEPHALOPATHY VIRUS 1975-92
Identificador DeCS: 19524
ID do descritor: D011328
Classificação da NLM: QU 55
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/01/1986
Data de entrada: 10/05/1985
Data de revisão: 27/05/2020
Prions - Conceito preferido
Identificador do conceito M0017586
Nota de escopo Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Termo preferido Prions
Termo(s) alternativo(s) Prion
Mink Encephalopathy Virus - Mais específico
Identificador do conceito M0017585
Termo preferido Mink Encephalopathy Virus
Termo(s) alternativo(s) Encephalopathy Virus, Mink



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