DeCS

Descritor em português:

Trombospondinas

Descritor em inglês:

Thrombospondins

Descritor em espanhol:

Trombospondinas

Espanhol da Espanha

Descritor

trombospondinas

Nota de escopo:

Familia de glicoproteínas de adhesión relacionadas que se sintetizan, segregan, e incorporan a la matriz extracelular de una variedad de células, incluidos los gránulos alfa de las plaquetas, trás la activación de la trombina y de las células endoteliales. Interactúan con un numeroso grupo de FACTORES DE LA COAGULACIÓN SANGUÍNEA y de factores anticoagulantes. Se han identificado cinco formas diferentes, trombospondina 1, -2, -3, -4, y matriz proteica oligomérica del cartílago (COMP). Intervienen en la adhesión celular, agregación plaquetaria, proliferación celular, angiogénesis, metástasis tumoral, crecimiento del MÚSCULO LISO VASCULAR, y en la reparación tisular.

Descritor em francês:

Thrombospondines

Termo(s) alternativo(s):

Thrombospondin

Código(s) hierárquico(s):

D09.400.430.890.895
D12.776.395.550.895
D12.776.543.550.895

Identificador Único RDF:

https://id.nlm.nih.gov/mesh/D019699

Nota de escopo:

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

Nota de indexação:

membrane glycoproteins; THROMBOSPONDIN 1 is also available

Qualificadores permitidos:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Identificador do conceito	M0029253
Nota de escopo	A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Termo preferido	Thrombospondins
Termo(s) alternativo(s)	Thrombospondin

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