Pesquisa
Descritor em português: Hipoxantina Fosforribosiltransferase
Descritor em inglês: Hypoxanthine Phosphoribosyltransferase
Descritor em espanhol: Hipoxantina Fosforribosiltransferasa
Descritor hipoxantina fosforribosiltransferasa
Termo(s) alternativo(s) HPRT
IMP pirofosforilasa
guanina fosforribosiltransferasa
hipoxantina-guanina fosforribosiltransferasa
Nota de escopo: Enzima que cataliza la conversión de 5-fosforribosil-1-pirofosfato e hipoxantina, guanina o MERCAPTOPURINA, en los 5'-mononucleótidos correspondientes y pirofosfato. La enzima es importante para la biosíntesis de la purinas, así como para ciertas funciones del sistema nervioso central. La ausencia completa de actividad enzimática se asocia al SÍNDROME DE LESCH-NYHAN, mientras que la deficiencia parcial provoca una hiperproducción de ácido úrico. EC 2.4.2.8.
Descritor em francês: Hypoxanthine phosphoribosyltransferase
Termo(s) alternativo(s): Guanine Phosphoribosyltransferase
HGPRT
HPRT
HPRTase
Hypoxanthine Guanine Phosphoribosyltransferase
Hypoxanthine-Guanine Phosphoribosyltransferase
IMP Pyrophosphorylase
Phosphoribosyltransferase, Guanine
Phosphoribosyltransferase, Hypoxanthine
Phosphoribosyltransferase, Hypoxanthine-Guanine
Pyrophosphorylase, IMP
Código(s) hierárquico(s): D08.811.913.400.725.450
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D007041
Nota de escopo: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Nota de indexação: /defic: consider also LESCH-NYHAN SYNDROME or GOUT; DF: note short X ref
Qualificadores permitidos: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: EC 2.4.2.8
Nome CAS Tipo 1: IMP:pyrophosphate phospho-D-ribosyltransferase
Indexação Anterior: Pentosephosphates (1972-1974)
Pentosyltransferases (1972-1974)
Nota MeSH pública: 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was indexed under PENTOSYLTRANSFERASES 1978-91
Nota Online: use HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (NM) to search GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1980-91
Nota histórica: 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91
Veja também os descritores: Gout MeSH
Lesch-Nyhan Syndrome MeSH
Identificador DeCS: 7221
ID do descritor: D007041
Documentos indexados na Biblioteca Virtual em Saúde (BVS): Clique aqui para acessar os documentos da BVS
Data de estabelecimento: 01/09/1975
Data de entrada: 11/11/1974
Data de revisão: 13/07/2017
Hypoxanthine Phosphoribosyltransferase - Conceito preferido
Identificador do conceito M0010952
Nota de escopo An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Termo preferido Hypoxanthine Phosphoribosyltransferase
Termo(s) alternativo(s) Guanine Phosphoribosyltransferase
HGPRT
HPRT
HPRTase
Hypoxanthine Guanine Phosphoribosyltransferase
Hypoxanthine-Guanine Phosphoribosyltransferase
IMP Pyrophosphorylase
Phosphoribosyltransferase, Guanine
Phosphoribosyltransferase, Hypoxanthine
Phosphoribosyltransferase, Hypoxanthine-Guanine
Pyrophosphorylase, IMP



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