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Descriptor English: Phleomycins
Descriptor Spanish: Fleomicinas
Descriptor fleomicinas
Scope note: Polipéptidos de bajo peso molecular, hidrosolubles, que contienen cobre, obtenidos del medio de cultivo de Streptomyces verticillus. Son inhibidores específicos de la síntesis de ADN por las bacterias y han demostrado actividad como agentes antitumorales. También se han utilizados contra la roya (infección por hongos) de las plantas.
Descriptor Portuguese: Fleomicinas
Descriptor French: Phléomycines
Entry term(s): Phleomycin
Tree number(s): D09.400.420.110.710
D12.644.233.110.710
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010692
Scope note: Water-soluble, copper-containing low molecular weight polypeptides obtained from the culture medium of Streptomyces verticillus. They are specific inhibitors of DNA synthesis in bacteria and have been found to act as antitumor agents. They have also been used against rust fungi of plants.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
Previous Indexing: Antibiotics (1971-1974)
Antibiotics, Antineoplastic (1971-1974)
Peptides (1971-1974)
Public MeSH Note: 91; was see under BLEOMYCINS 1981-90; was PHLEOMYCIN see under ANTIBIOTICS 1975-80
Online Note: use PHLEOMYCINS to search PHLEOMYCIN 1975-80
History Note: 91(81); was see under BLEOMYCINS 1981-90; was PHLEOMYCIN see under ANTIBIOTICS 1975-80
DeCS ID: 10886
Unique ID: D010692
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2004/07/07
Phleomycins - Preferred
Concept UI M0016611
Scope note Water-soluble, copper-containing low molecular weight polypeptides obtained from the culture medium of Streptomyces verticillus. They are specific inhibitors of DNA synthesis in bacteria and have been found to act as antitumor agents. They have also been used against rust fungi of plants.
Preferred term Phleomycins
Entry term(s) Phleomycin



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