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Descriptor English: Tamoxifen
Descriptor Spanish: Tamoxifeno
Descriptor tamoxifeno
Entry term(s) ICI-46474
Scope note: Uno de los MODULADORES SELECTIVOS DE LOS RECEPTORES DE ESTRÓGENO con actividades específicas de los tejidos. El tamoxifeno actúa como antiestrógeno (agente inhibidor) en el tejido mamario, pero como estrógeno (agente estimulador) en el metabolismo del colesterol, densidad ósea y proliferación celular en el ENDOMETRIO.
Descriptor Portuguese: Tamoxifeno
Descriptor French: Tamoxifène
Entry term(s): Citrate, Tamoxifen
ICI 46,474
ICI 46474
ICI 47699
ICI-46,474
ICI-46474
ICI-47699
ICI46,474
ICI46474
ICI47699
Nolvadex
Novaldex
Soltamox
Tamoxifen Citrate
Tomaxithen
Zitazonium
Tree number(s): D02.455.426.559.389.150.700.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013629
Scope note: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Estrogen Antagonists
Antineoplastic Agents, Hormonal
Selective Estrogen Receptor Modulators
Bone Density Conservation Agents
Registry Number: 094ZI81Y45
CAS Type 1 Name: Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-
Previous Indexing: Dimethylamines (1973-1974)
Phenyl Ethers (1974)
Stilbenes (1966-1974)
Public MeSH Note: 78; was see under STILBENES 1975-77
History Note: 78(75); was see under STILBENES 1975-77
DeCS ID: 14010
Unique ID: D013629
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/07/01
Tamoxifen - Preferred
Concept UI M0021024
Scope note One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Preferred term Tamoxifen
ICI-47699 - Narrower
Concept UI M0021027
Preferred term ICI-47699
Entry term(s) ICI 47699
ICI47699
Nolvadex - Narrower
Concept UI M0373247
Preferred term Nolvadex
Entry term(s) Novaldex
Tamoxifen Citrate - Narrower
Concept UI M0373246
Preferred term Tamoxifen Citrate
Entry term(s) Citrate, Tamoxifen
Tomaxithen - Narrower
Concept UI M0021028
Preferred term Tomaxithen
Zitazonium - Narrower
Concept UI M0021025
Preferred term Zitazonium
ICI-46474 - Narrower
Concept UI M0021026
Preferred term ICI-46474
Entry term(s) ICI 46,474
ICI 46474
ICI-46,474
ICI46,474
ICI46474
Soltamox - Narrower
Concept UI M0495698
Preferred term Soltamox



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