| Descriptor English: | Tamoxifen | ||||||
| Descriptor Spanish: | Tamoxifeno 
 | ||||||
| Descriptor Portuguese: | Tamoxifeno | ||||||
| Descriptor French: | Tamoxifène | ||||||
| Entry term(s): | Citrate, Tamoxifen ICI 46,474 ICI 46474 ICI 47699 ICI-46,474 ICI-46474 ICI-47699 ICI46,474 ICI46474 ICI47699 Nolvadex Novaldex Soltamox Tamoxifen Citrate Tomaxithen Zitazonium | ||||||
| Tree number(s): | D02.455.426.559.389.150.700.900 | ||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D013629 | ||||||
| Scope note: | One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. | ||||||
| Allowable Qualifiers: | AA                                                            analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine | ||||||
| Pharm Action: | Estrogen Antagonists Antineoplastic Agents, Hormonal Selective Estrogen Receptor Modulators Bone Density Conservation Agents | ||||||
| Registry Number: | 094ZI81Y45 | ||||||
| CAS Type 1 Name: | Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)- | ||||||
| Previous Indexing: | Dimethylamines (1973-1974) Phenyl Ethers (1974) Stilbenes (1966-1974) | ||||||
| Public MeSH Note: | 78; was see under STILBENES 1975-77 | ||||||
| History Note: | 78(75); was see under STILBENES 1975-77 | ||||||
| DeCS ID: | 14010 | ||||||
| Unique ID: | D013629 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1978/01/01 | ||||||
| Date of Entry: | 1974/11/11 | ||||||
| Revision Date: | 2016/07/01 | 
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                                    - 
                                        CHEMICALS AND DRUGS
 
 Organic Chemicals [D02]Organic Chemicals
|  | 
                        
                                                                    
                        Tamoxifen                                            
                                        - Preferred                                        
                                                                
                                
                        
                        
                        
                                                                    
                        ICI-47699                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Nolvadex                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Tamoxifen Citrate                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Tomaxithen                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Zitazonium                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        ICI-46474                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Soltamox                                            
                                        - Narrower                                        
                                                                
                                
                        
                        
                    
                    
                
                | Concept UI | M0021024 | 
| Scope note | One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. | 
| Preferred term | Tamoxifen | 
| Concept UI | M0021027 | 
| Preferred term | ICI-47699 | 
| Entry term(s) | ICI 47699 ICI47699 | 
| Concept UI | M0373247 | 
| Preferred term | Nolvadex | 
| Entry term(s) | Novaldex | 
| Concept UI | M0373246 | 
| Preferred term | Tamoxifen Citrate | 
| Entry term(s) | Citrate, Tamoxifen | 
| Concept UI | M0021028 | 
| Preferred term | Tomaxithen | 
| Concept UI | M0021025 | 
| Preferred term | Zitazonium | 
| Concept UI | M0021026 | 
| Preferred term | ICI-46474 | 
| Entry term(s) | ICI 46,474 ICI 46474 ICI-46,474 ICI46,474 ICI46474 | 
| Concept UI | M0495698 | 
| Preferred term | Soltamox | 
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